ERMAP,红细胞膜相关蛋白ERMAP抗体

产品编号HZ-12333R
英文名称ERMAP
中文名称红细胞膜相关蛋白ERMAP抗体
别 名ERMAP; ERMAP_HUMAN; Erythroblast membrane associated protein; Erythroid membrane associated protein; Erythroid membrane-associated protein; hERMAP; MGC118810; MGC118811; MGC118812; MGC118813; PRO2801; Radin blood group (Rd); Radin blood group antigen; RD; SC; Scianna blood group (Sc); Scianna blood group antigen.
说 明 书0.1ml 0.2ml
研究领域细胞生物 发育生物学 信号转导 干细胞 细胞膜蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat,
ERMAP,红细胞膜相关蛋白ERMAP抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量50kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human ERMAP
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
ERMAP,红细胞膜相关蛋白ERMAP抗体PubMedPubMed
产品介绍background:
ERMAP is a single-pass type one membrane protein that belongs to the immunoglobulin superfamily. Expressed in cord blood, fetal liver and adult bone marrow, ERMAP is thought to function as a cell adhesion molecule in erythroid cells and is responsible for expression of the Scianna/Radin (Sc/Rd) blood group antigen system. The Sc/Rd system is comprised of seven antigens that are present on the surface of red blood cells and have a variety of functions ranging from protein transport to cell adhesion. These seven blood antigens can differ in their expression within a population and may sometimes differ between mother and child. A fetus expressing different blood antigens than its mother may cause the mother to produce antibodies against the fetal blood. This condition is known as hemolytic disease of the newborn (HDN) and is characterized by jaundice, anemia and in some cases, infant death.

Function:
Possible role as a cell-adhesion or receptor molecule of erythroid cells.

Subunit:

Subcellular Location:
Cell membrane. Cytoplasm.

Tissue Specificity:
Expressed in erythroid-enriched bone marrow (at protein level). Highly expressed in bone marrow and to a lower extent in leukocytes, thymus, lymph node and spleen.

Post-translational modifications:
Glycosylated.

ERMAP,红细胞膜相关蛋白ERMAP抗体Similarity:
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Contains 1 B30.2/SPRY domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Gene ID:
114625

Database links:
Entrez Gene: 114625 Human
Entrez Gene: 27028 Mouse
Entrez Gene: 298485 Rat
Omim: 609017 Human
SwissProt: Q96PL5 Human
SwissProt: Q9JLN5 Mouse
Unigene: 439437 Human
Unigene: 290753 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.