FITC标记的转录因子CP2抗体
产品名称： FITC标记的转录因子CP2抗体
英文名称： Anti-TFCP2C/FITC
产品编号： HZ-9852R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-TFCP2C/FITC Conjugated antibody
FITC标记的转录因子CP2抗体
| 产品编号 | bs-9852R-FITC |
| 英文名称 | Anti-TFCP2C/FITC |
| 中文名称 | FITC标记的转录因子CP2抗体 |
| 别 名 | Alpha globin transcription factor CP2; CP2; LBP 1C; LBP1C; LSF; SAA3 enhancer factor; SEF; TFCP2; TFCP2C; Transcription factor CP2; Transcription factor LSF; TFCP2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 心血管 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 57kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TFCP2C |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: CP2 family gene products are reported to be involved in a-globin gene expression. Mouse CP2c (also known as a-CP2/CP2/LSF/UBP-1) is a homologue of human LBP-1c with 96% amino acid sequence identity. CP2c was initially identified as an activator of the mouse a-globin gene, which binds to the consensus DNA-binding sequence CNRG-N6-CNR(G/C) within a promoter element overlapping the CCAAT box. The transcriptional activity of CP2c was increased during induced differentiation of MEL cells and associated globin gene transcription. CP2c is also likely to be involved in regulation of non-globin erythroid-specific genes. It was reported that congenital erythropoietic porphyria was caused by the mutations in GATA-1 and CP2c binding sites within the promoter of the uroporphyrinogen III synthase gene, the fourth enzyme in the heme biosynthetic pathway. Function: Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1. Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter. Subunit: Binds to DNA as a dimer, isoform 3 does not bind to DNA or affect the binding of isoform 1 to DNA. Interacts with UBP1 and PIAS1, and is probably part of a complex containing TFCP2, UBP1 and PIAS1. Component of the SSP (stage selector protein) complex, which appears to be a heteromer of TFCP2 and 2 copies of NFE4. Subcellular Location: Nuclear. Tissue Specificity: Ubiquitous. Expressed in brain, ovary, kidney, thymus, spleen, liver, adrenal, heart and lung (at protein level). Similarity: Belongs to the grh/CP2 family. CP2 subfamily. Database links: Entrez Gene: 7024 Human Entrez Gene: 21422 Mouse Entrez Gene: 315309 Rat Omim: 189889 Human SwissProt: Q7T2U9 Chicken SwissProt: Q12800 Human SwissProt: Q9ERA0 Mouse Unigene: 48849 Human Unigene: 219040 Mouse Unigene: 202290 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
CP2家族基因产物参与了A珠蛋白基因的表达。小鼠CP2C（又名ApCP2/CP2/LSF/UBP-1）是96%个氨基酸序列同源的人LBP1C同源物。CP2C最初被鉴定为小鼠A珠蛋白基因的激活剂，其与CCAAT盒重叠的启动子元件中的一致的DNA结合序列CNRG-N6CNR（G/C）结合。在诱导分化的MeL细胞和相关珠蛋白基因转录过程中，CP2C的转录活性增加。CP2C也可能参与调节非珠蛋白红系特异性基因。据报道，先天性红细胞生成卟啉症是由GATA-1和CP2C结合位点在尿卟啉原III合成酶基因启动子（第四个血红素生物合成途径）中引起的突变引起的。