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上海信裕生物科技有限公司
PGRMC1抗体

PGRMC1抗体

商家询价

产品名称： PGRMC1抗体

英文名称： PGRMC1Antibody

产品编号： XY12990-1-

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

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 PGRMC1抗体Applications

In-house applications ELISA, WB, IHC, IP     Application not tested? Please see our Guarantee.
Published applications IHC, WB Publications 4 citations –view here
Species specificity Human,Mouse,Rat; other species not tested.
Published Species Human
Images
Prev1NextView more validation data
  • 12990-1-AP;HEK-293 cellsHEK-293 cells were subjected to SDS PAGE followed by western blot with 12990-1-AP(PGRMC1 antibody) at dilution of 1:400
  • 12990-1-AP;human cervical cancerImmunohistochemical of paraffin-embedded human cervical cancer using 12990-1-AP(PGRMC1 antibody) at dilution of 1:100 (under 10x lens)
  • 12990-1-AP;MCF-7 cellsIP Result of anti-PGRMC1 (IP:12990-1-AP, 3ug; Detection:12990-1-AP 1:1000) with MCF-7 cells lysate 1600ug.
Positive WB detected in HEK-293 cells, HepG2 cells, human brain tissue, human liver tissue, MCF7 cells, mouse kidney tissue, mouse liver tissue, mouse ovary tissue
Positive IP detected in MCF-7 cells
Positive IHC detected in Human cervical cancer tissue, human lung cancer tissue, human ovary tumor tissue
Recommended dilution WB : 1:500-1:5000
IP : 1:500-1:5000
IHC : 1:20-1:200
 PGRMC1抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information PGRMC1抗体
Immunogen PGRMC1 fusion protein ag3643 Full name Progesterone receptor membrane component 1
Calculated molecular
weight		 195aa,22 kDa Observed molecular 
weight		 22-28 kDa
GenBank accession 
number		 BC034238 Gene ID (NCBI) 10857
Gene symbol PGRMC1 Synonyms HPR6.6, MPR, PGRMC, PGRMC1
Background

Progesterone receptor membrane component 1 (PGRMC1) is a member of a multi-protein progesterone-binding complex. However, PGRMC1 shares homology with cytochrome b5-related proteins rather than hormone receptors (PMID: 18992768). It is a heme binding protein with biding sites for Src homology (SH2) and SH3 domain-containing proteins (PMID: 17583495). PGRMC1 is overexpressed in a variety of cancers, and thus represents an important biomarker for cancer progression and a potential target for anticancer drugs (PMID: 21730960). In nonmalignant tissues, PGRMC1 is highly expressed in the liver and kidney (PMID: 9705155; 20164297). PGRMC1抗体

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