FITC标记的DNA聚合酶δ 抗体
产品名称： FITC标记的DNA聚合酶δ 抗体
英文名称： Anti-DNA polymerase delta/FITC
产品编号： HZ-7416R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-DNA polymerase delta/FITC Conjugated antibod
FITC标记的DNA聚合酶δ 抗体
| 英文名称 | Anti-DNA polymerase delta/FITC |
| 中文名称 | FITC标记的DNA聚合酶δ 抗体 |
| 别 名 | DNA polymerase delta subunit 2; DNA polymerase delta subunit p50; DNA polymerase subunit delta 2; DNA polymerase subunit delta p50; DPOD2_HUMAN; POLD 2; POLD2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 染色质和核信号 信号转导 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 51kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from Human DNA polymerase delta |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: DNA replication, recombination and repair, all of which are necessary for genomic stability, require the presence of exonucleases (1). In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches (2). These exonucleases include the family of DNA polymerases (3). DNA pol α, β, ∂, and e are involved in DNA replication and repair (4). DNA pol ∂ and DNA pol e are multisubunit enzymes, with DNA pol ∂ consisting of two subunits p125, which interacts with the sliding DNA clamp protein PCNA, and p50 (5). The nuclear-encoded DNA pol © is the only DNA polymerase required for the replication of the mitochondrial DNA (6). DNA pol Ω is ubiquitously expressed in various tissues and mediates the cellular mechanism of damage-induced mutagenesis (7). DNA pol œ is a DNA polymerase-helicase that binds ATP and is involved in the repair of interstrand crosslinks (8). Function: The function of the small subunit is not yet clear. Subcellular Location: Nucleus. Similarity: Belongs to the DNA polymerase delta/II small subunit family. Database links: Entrez Gene: 281991 Cow Entrez Gene: 5425 Human Entrez Gene: 18972 Mouse Entrez Gene: 289758 Rat Omim: 600815 Human SwissProt: P49004 Cow SwissProt: P49005 Human SwissProt: O35654 Mouse SwissProt: Q6AXY4 Rat Unigene: 306791 Human Unigene: 35788 Mouse Unigene: 22989 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
DNA的复制、重组和修复，所有这些都是基因组稳定性所必需的，需要存在外切核酸酶（1）。在DNA复制中，这些酶参与冈崎片段的加工，而在DNA修复中，它们起切除受损的DN**段和纠正重组失配的作用(2)。这些核酸外切酶包括DNA聚合酶家族（3）。DNA POLα、β、γ、E参与了DNA的复制和修复（4）。DNA pol_和DNA pol e是多亚基酶，DNA pol_由两个亚基p125和p50(5)组成，这两个亚基与滑动DNA钳位蛋白PCNA相互作用。核编码的DNA聚合酶是复制线粒体DNA所需的唯一的DNA聚合酶（6）。DNA POLΩ在多种组织中广泛表达，介导损伤诱变的细胞机制（7）。DNA聚合酶是一种结合ATP的DNA聚合酶解旋酶，参与了链间交联的修复（8）。