FITC标记的钙整合素结合蛋白1抗体
产品名称： FITC标记的钙整合素结合蛋白1抗体
英文名称： Anti-CIB1/FITC
产品编号： HZ-1682R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-CIB1/FITC Conjugated antibody
FITC标记的钙整合素结合蛋白1抗体
| 英文名称 | Anti-CIB1/FITC |
| 中文名称 | FITC标记的钙整合素结合蛋白1抗体 |
| 别 名 | Sip2-28; Cibkip; Kip; Prkdcip; CIB1_HUMAN; Calcium and integrin-binding protein 1;CIB;Calcium- and integrin-binding protein;CIBP;Calmyrin;DNA-PKcs-interacting protein;Kinase-interacting protein;KIP;SNK-interacting protein 2-28;SIP2-28. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 转运蛋白 细胞粘附分子 结合蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 22kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CIB1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: CIB1(Calcium and integrin binding 1) may convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through the binding to the integrin cytoplasmic domain. Function: May convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Subunit: Monomer. Interacts with the heterodimeric integrin alpha-IIb/beta3. Interacts with the protein kinases PLK2/SNK and with the region immediately upstream of the kinase domain of DNA-PK. Interacts with PLK3; leading to inhibit PLK3 kinase activity. Interacts with PSEN2. Interacts with MYO1C (By similarity). Interacts (via C-terminus) with F8. Interacts with NBR1 (via C-terminus). Interacts with FEZ1 (via C-terminus). Interacts with UBR5 (via C-terminus); the interaction is sensitive to DNA damage, and may target CIB1 for ubiquitin-mediated degradation. Interacts with IFI6. Interacts with BCL2. Interacts with TAS1R2 (via C-terminus); this interaction is independent of the myristoylation state of CIB1. Interacts with ITPR3; in a calcium dependent manner. Interacts with PTK2/FAK1. Interacts with MAP3K5; inhibiting MAP3K5 activation by phosphorylation, and its subsequent interaction with TRAF2. Subcellular Location: Membrane. Cytoplasm. Nucleus. Cell projection, filopodium. Apical cell membrane. Localizes to the perinuclear region in the presence of NBR1. Colocalizes with TAS1R2 in apical regions of taste receptor cells. Tissue Specificity: Ubiquitous. Similarity: Contains 2 EF-hand domains. Database links: Entrez Gene: 10519 Human Omim: 602293 Human SwissProt: Q99828 Human Unigene: 715556 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CIB1是通过抑制eurekalert AK1（p21蛋白激酶）来发挥作用的。当CIB1激活PAK1后，会促发一系列蛋白磷酸化，从而抑制细胞迁移。CIB1在抑制肿瘤转移中有很重要的作用 |
CIB1(钙和整合素结合1)可通过与整合素胞浆结构域的结合将整合素α-IIb/β3的非活性构象转化为活性形式。