FITC标记的肿瘤坏死因子相关凋亡诱导配体抗体
产品名称： FITC标记的肿瘤坏死因子相关凋亡诱导配体抗体
英文名称： Anti-TRAIL/FITC
产品编号： HZ-1214R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-TRAIL/FITC Conjugated antibody
FITC标记的肿瘤坏死因子相关凋亡诱导配体抗体
| 英文名称Anti-TRAIL/FITC中文名称FITC标记的肿瘤坏死因子相关凋亡诱导配体抗体别 名APO2L; TNFSF10; Apo 2 ligand; Apo 2L; CD 253; CD253; CD253 antigen; Protein TRAIL; TL 2; TL2; TNF Related Apoptosis Inducing Ligand; TNF related apoptosis inducing ligand TRAIL; TNFSF 10; TNFSF10 protein; TRAIL; TRAIL PEN; Tumor Necrosis Factor (ligand) Superfamily Member 10; TNF10_HUMAN. 规格价格100ul/2980元 购买 大包装/询价说 明 书100ul 研究领域肿瘤 细胞生物 神经生物学 信号转导 细胞凋亡 抗体来源Rabbit克隆类型Polyclonal交叉反应Human, Mouse, Rat, 产品应用IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.分 子 量31kDa细胞定位细胞膜 性 状Lyophilized or Liquid浓 度1mg/ml免 疫 原KLH conjugated synthetic peptide derived from human TRAIL亚 型IgG纯化方法affinity purified by Protein A储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.产品介绍background: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3.(tumor necrosis factor-related apoptosis-inducing ligand) Function: Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. Subunit: Homotrimer. Subcellular Location: Membrane; Single-pass type II membrane protein (Potential). Tissue Specificity: Widespread; most predominant in spleen, lung and prostate. Similarity: Belongs to the tumor necrosis factor family. Database links: Entrez Gene: 8743 Human Entrez Gene: 22035 Mouse Entrez Gene: 246775 Rat Omim: 603598 Human SwissProt: P50591 Human SwissProt: P50592 Mouse Unigene: 478275 Human Unigene: 1062 Mouse Unigene: 83627 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 肿瘤坏死因子相关的凋亡诱导配体(TNF related apoptosis inducingligand，TRAIL)又称凋亡素2配体(Apo2 ligand，Apo2L)或死亡配体，属于肿瘤坏死因子家族，能选择性的诱导肿瘤细胞凋亡，而正常细胞则可以逃逸他的杀伤作用，有望成为一种新的抗肿瘤方法。 |
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由该基因编码的蛋白质是属于肿瘤坏死因子（TNF）配体家族的细胞因子。该蛋白优先诱导转化细胞和肿瘤细胞中的细胞凋亡，但在正常组织中以显著水平表达，但似乎不杀死正常细胞。该蛋白与TNF-受体超家族的几个成员结合，包括TNFRSF10A/TRAILR1、TNFRSF10B/TRAILR2、TNFRSF10C/TRAILR3、TNFRSF10D/TRAILR4，并且也可能是TNFRSF11B/OPG。该蛋白的活性可以通过与诱骗受体TNFRSF10C/TRAILR3、TNFRSF10D/TRAILR4和TNFRSF11B/OPG结合而不能诱导细胞凋亡来调节。该蛋白与其受体的结合已被证明触发MAPK8/JNK、caspase 8和caspase 3的活化（肿瘤坏死因子相关凋亡诱导配体）。