FITC标记的ZCH11蛋白抗体
产品名称： FITC标记的ZCH11蛋白抗体
英文名称： Anti-ZCH11/FITC
产品编号： HZ-18565R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-ZCH11/FITC Conjugated antibody
FITC标记的ZCH11蛋白抗体
| 英文名称 | Anti-ZCH11/FITC |
| 中文名称 | FITC标记的ZCH11蛋白抗体 |
| 别 名 | DKFZp779C1943; EC 2.7.7.52; FLJ42878; KIAA0191; PAP associated domain containing 3; PAPD3; Terminal uridylyltransferase 4; TUT4; TUT4_HUMAN; TUTase 4; ZCCHC 11; ZCCHC11; Zinc finger CCHC domain containing 11; Zinc finger CCHC domain containing protein 11; Zinc finger CCHC domain-containing protein 11. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 转录调节因子 锌指蛋白 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 185kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ZCH11 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: ZCCHC11 is an RNA uridyltransferase (EC 2.7.7.52) that uses UTP to add uridines to the 3-prime end of substrate RNA molecules (Jones et al., 2009 [PubMed 19701194]).[supplied by OMIM, Jan 2011] Function: Uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. Catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. Does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and LIN28B. Also catalyzes the 3' uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation. Subcellular Location: Nucleus. Cytoplasm. Translocates into the cytoplasm following treatment of the cell with LPS. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the DNA polymerase type-B-like family. Contains 3 CCHC-type zinc fingers. Contains 2 PAP-associated domains. Database links: Entrez Gene: 23318 Human Entrez Gene: 230594 Mouse Entrez Gene: 313481 Rat Omim: 613692 Human SwissProt: Q5TAX3 Human SwissProt: B2RX14 Mouse Unigene: 655407 Human Unigene: 25181 Mouse Unigene: 446602 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
ZCCHC11是一种RNA尿苷转移酶(EC 2.7.7.52)，使用UTP将尿苷添加到底物RNA分子的3质端(Jones等人，2009[PubMed 19701194])。